This is in contrast to conventional systemic circulation via the gut and liver as shown in the figure below on the left. Once in the lymphatic vessels, they are transported to mesenteric lymph nodes associated with the gastrointestinal (GI) tract where they pass into larger lymphatic vessels connected to the thoracic duct, then merge with systemic circulation as illustrated in the figure below on the right.
Chylomicrons are too large to enter blood vessels and are instead taken up by submucosal lymphatic vessels.
Triglycerides, which are composed of three fatty acid chains tethered to a 3-carbon glycerol molecule, are absorbed by small intestine mucosal enterocytes where they are incorporated into large lipid-protein complexes (chylomicrons) and released into the submucosa. Importantly, many consumed dietary lipids, particularly triglycerides, enter systemic circulation by an alternate route. Consumed nutrients and most orally administered pharmaceuticals are initially absorbed by the small intestine mucosa, distributed to the liver by the portal vein before entering systemic circulation. We are advancing a synthetic lymphatic-targeting chemistry platform called Glyph, which is designed to employ the lymphatic system’s natural lipid absorption and transport process and has led to the nomination of LYT-300 for continued expansion of our Wholly Owned Pipeline.
Lymphatic-targeting chemistry platform leveraging the body's natural lipid absorption and transport process to orally administer drugs via the lymphatic system
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